{"id":89503,"date":"2024-02-16T10:35:14","date_gmt":"2024-02-16T09:35:14","guid":{"rendered":"https:\/\/www.kiwidatascience.com\/?post_type=showcase&p=89503"},"modified":"2024-03-06T09:55:41","modified_gmt":"2024-03-06T08:55:41","slug":"pqr","status":"publish","type":"showcase","link":"https:\/\/www.kiwidatascience.com\/it\/showcase\/pqr\/","title":{"rendered":"Product Quality Review"},"content":{"rendered":"
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Case overview<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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As part of regulatory requirements, Pharmatech is subject to regular inspections by the Food and Drug Administration (FDA) to ensure compliance with Good Manufacturing Practices (GMP) and other regulations. In preparation for the FDA inspection, Pharmatech is required to produce an Annual Product Quality Review (APQR) for each of its marketed drugs.<\/p>

To support the findings presented in the APQR and ensure the accuracy of the data analysis, Pharmatech decides to enlist the expertise of Kiwi Data Science. This analysis involves assessing the distribution, the stability of the process and the evaluation of various performance metrics such as Cp, Pp, Cps and Ppk.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Tecnologie<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Distribution<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A distribution analysis involves examining how data points are spread out within a dataset. It includes techniques like frequency distribution, histograms, descriptive statistics, and probability distributions. The goal is to understand the pattern, central tendency, variability, and shape of the data distribution. This analysis helps in identifying outliers, assessing normality, and making informed decisions based on the data’s characteristics.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Control chart<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A control chart is a graphical representation of process data over time. It typically includes a central line representing the mean or target value and upper and lower control limits, which are set based on historical data or established standards. Data points falling within these limits indicate that the process is in control, while points outside the limits suggest variation that may require investigation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Capability<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Capability analysis evaluates whether a process can consistently produce outputs within specified limits. It typically involves calculating indices such as Cp<\/strong>, Cpk<\/strong>, Pp<\/strong>, or Ppk<\/strong>, which compare the spread of process variation to the width of the specification limits. These indices provide insights into the process capability, indicating how well it meets customer requirements and whether adjustments are needed to improve quality and efficiency.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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QQ-Plot<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The distribution has been investigated from the quantitative point of view using \u00a0several statistical tests (Anderson Darling, Kolmogorov Smirnov, Ryan-Joiner). In addition, qualitative considerations have been obtained thanks to the use of the QQ-Plot<\/strong>.<\/p>

The exploration of 73 different distributions provided by the software Scarlet, allowed us to identify the Weibull as the best choice.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Performance<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Finally Cp<\/strong>, Cpk<\/strong>, Pp<\/strong> and Ppk<\/strong> KPIs have been calculated providing a complete and detailed description of the Short<\/strong> and Long<\/strong> term capability of the process.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Results<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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In conclusion, after carefully evaluating the quality of the pharmaceutical process across various criteria, it was evident that it met or exceeded expectations in several key areas. From its effectiveness and safety to its regulatory compliance and the quality of the final product, the process demonstrated a commendable level of precision and reliability. Although there may have been areas for improvement, such as optimizing production times or implementing more advanced technologies, overall, it stood out as a reliable and high-quality pharmaceutical operation.<\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Statistical process analysis for a Product Quality Review<\/p>","protected":false},"featured_media":89487,"template":"","meta":[],"case_category":[266,256,257,268],"class_list":["post-89503","showcase","type-showcase","status-publish","has-post-thumbnail","hentry","case_category-industrial-statistics","case_category-machine-learning","case_category-monitoring","case_category-pharmaceutical"],"yoast_head":"\nProduct Quality Review - Kiwi Data Science<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kiwidatascience.com\/it\/showcase\/pqr\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Product Quality Review - Kiwi Data Science\" \/>\n<meta property=\"og:description\" content=\"Statistical process analysis for a Product Quality Review\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.kiwidatascience.com\/it\/showcase\/pqr\/\" \/>\n<meta property=\"og:site_name\" content=\"Kiwi Data Science\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/kiwidatascience\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-06T08:55:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.kiwidatascience.com\/wp-content\/uploads\/2023\/01\/pexels-artem-podrez-5726850-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1440\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@KiwiDataScience\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.kiwidatascience.com\/showcase\/pqr\/\",\"url\":\"https:\/\/www.kiwidatascience.com\/showcase\/pqr\/\",\"name\":\"Product Quality Review - 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